What is Tumor Mutation Burden (TMB)?

And why should you care about it in your cancer treatment plan?

When it comes to cancer, there’s so much more going on beneath the surface than just the type of cancer or location of your tumor. 

One of the most powerful – and often overlooked – factors in determining your treatment options is something called Tumor Mutation Burden (TMB).

In this educational video, taken from one of our recent LIVE Office Hours Zoom calls, molecular oncology scientist and cancer expert, Alex Rolland, explains:

  • – What TMB actually is 
  • – How a high or low TMB can dramatically impact your response to treatment – particularly immunotherapy
  • – Why it’s important to know your TMB status early in your cancer journey
  • – What you can do to ensure TMB is properly tested and used to guide your treatment decisions

So watch this short video (under 4 mins) and let us know if you have any questions.

Sign Up for our Online Precision Cancer Medicine Support Group

This video is from our Live Office Hours series, which happens monthly for members of our Cancer: Just the Facts program.

If you’d like to join our next Live Office Hours, just sign up for Cancer: Just the Facts! 

You’ll also receive access to many more educational videos and materials on Precision Cancer Medicine – that we only share inside of this special support group. Join hundreds of other patients who are already part of our growing community and learning how to advocate for better care. You are not alone.

Patient Success Story: Why TMB Can Make All the Difference

You may also want to take a look at Korey’s story. Korey is a patient of ours who was dealing with stage IV cancer. His doctor had told him there were no more options left. He and his wife contacted our team and we immediately got him proper diagnostics.

From our comprehensive genetic testing panel, our research team determined that Korey had an incredibly high Tumor Mutation Burden – and this was actually a good thing, because it meant we were able to recommend the exact right drug that would work to eradicate his cancer. We advocated for this treatment and Korey got it fully covered!

More than that, it worked perfectly – within just a few months he was free of cancer.

You can read Korey’s story here: Surviving Stage 4 Cancer: Korey Shares His Story

Reach Out for Support to Enhance Your Cancer Care

As we always say, knowledge is power!

Want to find out what is possible for you in cancer treatment today?

Just click on whichever offer fits you best: 

Register for a Precision Second Opinion with Alex Rolland 

Book a free Cancer Care Consultation (30 mins) with me, Michelle 

Join our free online program “Cancer: Just the Facts” 

As always, please reach out anytime if you have questions. We’re here to support you.

Published by on September 2, 2025